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Article

EMT-like circulating tumor cells in ovarian cancer patients are enriched by platinum-based chemotherapy.

Oncotarget - 25 Jul 2017

Chebouti Issam, Kasimir-Bauer Sabine, Buderath Paul, Wimberger Pauline, Hauch Siegfried, Kimmig Rainer, Kuhlmann Jan Dominik

Abstract excerpt

BACKGROUND: Assuming that tumor cell dissemination requires a shift to a mesenchymal phenotype, we analyzed the incidence of epithelial-to-mesenchymal-transition (EMT)-like circulating tumor cells (CTCs) in ovarian cancer patients and inquired, how their molecular phenotypes respond to platinum-based chemotherapy and influence outcome. RESULTS: Before surgery, overall detection rate for epithelial CTCs was 18%....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class Ia Phosphatidylinositol 3-Kinase

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Source

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Identifiers

PMID: 28415744
DOI: 10.18632/oncotarget.16179
PMCID: PMC5564727

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