Article
High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells.
Stem cell reports - 11 Apr 2017
D'Antonio Matteo, Woodruff Grace, Nathanson Jason L, D'Antonio-Chronowska Agnieszka, Arias Angelo, Matsui Hiroko, Williams Roy, Herrera Cheryl, Reyna Sol M, Yeo Gene W, Goldstein Lawrence S B, Panopoulos Athanasia D, Frazer Kelly A
Abstract excerpt
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyocytes. To date, studies have been published that use small panels of iPSC-derived cell lines to study monogenic diseases. However, to study complex diseases, where the...
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