Article
From epigenetic landscape to phenotypic fitness landscape: Evolutionary effect of pathogens on host traits.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2017
Cortez Mark Jayson V, Rabajante Jomar F, Tubay Jerrold M, Babierra Ariel L
Abstract excerpt
The epigenetic landscape illustrates how cells differentiate through the control of gene regulatory networks. Numerous studies have investigated epigenetic gene regulation but there are limited studies on how the epigenetic landscape and the presence of pathogens influence the evolution of host traits. Here, we formulate a multistable decision-switch model involving several phenotypes with the antagonistic...
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