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Article

A multicenter phase II study of personalized FOLFIRI-cetuximab for safe dose intensification.

Seminars in oncology - 1 Feb 2017

Boisdron-Celle Michèle, Metges Jean Philippe, Capitain Olivier, Adenis Antoine, Raoul Jean Luc, Lecomte Thierry, Lam You Heng, Faroux Roger, Masliah Claude, Poirier Anne Lise, Berger Virginie, Morel Alain, Gamelin Erick

Abstract excerpt

We conducted a multicenter proof of concept phase II trial in patients with advanced colorectal cancer receiving FOLFIRI-cetuximab regimens to explore individual drug tailoring using pharmacogenetics and pharmacokinetics (PK) monitoring. Patients were stratified by their pharmacogenetic/phenotypic status: the irinotecan dose was adjusted according to the number of TA tandem repeats in the UGT1A1 promoter, while...

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PMID: 28395759
DOI: 10.1053/j.seminoncol.2017.02.007

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KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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