Article
Increased Extra-axial Cerebrospinal Fluid in High-Risk Infants Who Later Develop Autism.
Biological psychiatry - 1 Aug 2017
Shen Mark D, Kim Sun Hyung, McKinstry Robert C, Gu Hongbin, Hazlett Heather C, Nordahl Christine W, Emerson Robert W, Shaw Dennis, Elison Jed T, Swanson Meghan R, Fonov Vladimir S, Gerig Guido, Dager Stephen R, Botteron Kelly N, Paterson Sarah, Schultz Robert T, Evans Alan C, Estes Annette M, Zwaigenbaum Lonnie, Styner Martin A, Amaral David G, Piven J, Hazlett H C, Chappell C, Dager S, Estes A, Shaw D, Botteron K, McKinstry R, Constantino J, Pruett J, Schultz R, Zwaigenbaum L, Elison J, Evans A C, Collins D L, Pike G B, Fonov V, Kostopoulos P, Das S, Gerig G, Styner M, Gu H, Piven Joseph
Abstract excerpt
BACKGROUND: We previously reported that infants who developed autism spectrum disorder (ASD) had increased cerebrospinal fluid (CSF) in the subarachnoid space (i.e., extra-axial CSF) from 6 to 24 months of age. We attempted to confirm and extend this finding in a larger independent sample. METHODS: A longitudinal magnetic resonance imaging study of infants at risk for ASD was carried out on 343 infants, who...
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