Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.

doi:10.1186/s40360-017-0132-y

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.

BMC pharmacology & toxicology - 8 Apr 2017

Xu Yuanyuan, Wang Yan, Zhi Jixin, Qi Lichun, Zhang Tong, Li Xueqi

Abstract excerpt

BACKGROUND: Genetic variation of matrix metalloproteinase 9 (MMP-9) gene polymorphism has been suggested to modulate coronary heart diseases (CHD), yet the underlying mechanisms are not well understood. METHODS: We investigated the association of MMP9 rs3918242 single nucleotide polymorphism with inflammation and lipid-lowering efficacy after simvastatin treatment in Chinese patients with CHD. Fasting serum lipid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Cholesterol, LDL

Share to Coronary Disease

Share to Genetic Variation

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Matrix Metalloproteinase 9

Share to Simvastatin

Source

Open in PubMed Open full text

Identifiers

PMID: 28390432
DOI: 10.1186/s40360-017-0132-y
PMCID: PMC5385050

Genes

MMP9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of matrix metalloproteinase 9 rs3918242 genetic variant on lipid-lowering efficacy of simvastatin therapy in Chinese patients with coronary heart disease.PMID 28390432Read ↗

Association between matrix metalloproteinase-9 rs3918242 polymorphism and development of coronary artery disease in a Chinese population.Semantic proximity Read ↗

Association of genetic polymorphisms in matrix metalloproteinase-9 and coronary artery disease in the Chinese Han population: a case-control study.Semantic proximity Read ↗

Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis.Semantic proximity Read ↗

The association between Matrix Metallo-proteinases-9 (MMP-9) gene family polymorphisms and risk of Coronary Artery Disease (CAD): a systematic review and meta-analysis.Semantic proximity Read ↗

Association of matrix metalloproteinase 9 genotypes and cardiovascular disease risk factors with serum matrix metalloproteinase 9 concentrations in Taiwanese individuals.Semantic proximity Read ↗

Association of MMP9 Polymorphism With Myocardial InfarctionSemantic proximity Read ↗

[Influence of PCSK9 gene E670G polymorphism on the risk of atherosclerotic coronary heart disease and plasma lipid level].Semantic proximity Read ↗

Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis.Semantic proximity Read ↗

Genetic association analysis between IL9 and coronary artery disease in a Chinese Han population.Semantic proximity Read ↗

The Association between Single Nucleotide Polymorphisms, including miR-499a Genetic Variants, and Dyslipidemia in Subjects Treated with Pharmacological or Phytochemical Lipid-Lowering Agents.Semantic proximity Read ↗

Association of MMP-9 and TIMP1 Genes Expression With Pro-inflammatory Cytokines in Patients With Coronary Artery DiseaseSemantic proximity Read ↗

Meta-analysis of MMP9-562C/T and the risk of coronary heart disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.