Article
Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics.
Assay and drug development technologies - 1 Apr 2017
Pulley Jill M, Shirey-Rice Jana K, Lavieri Robert R, Jerome Rebecca N, Zaleski Nicole M, Aronoff David M, Bastarache Lisa, Niu Xinnan, Holroyd Kenneth J, Roden Dan M, Skaar Eric P, Niswender Colleen M, Marnett Lawrence J, Lindsley Craig W, Ekstrom Leeland B, Bentley Alan R, Bernard Gordon R, Hong Charles C, Denny Joshua C
Abstract excerpt
The potential impact of using human genetic data linked to longitudinal electronic medical records on drug development is extraordinary; however, the practical application of these data necessitates some organizational innovations. Vanderbilt has created resources such as an easily queried database of >2.6 million de-identified electronic health records linked to BioVU, which is a DNA biobank with more than...
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