Multi-infarct dementia of Swedish type is caused by a 3’UTR mutation of COL4A1

Abstract excerpt

Sir, Cerebral small vessel diseases (cSVDs) often present as sporadic conditions but several monogenic families have also been reported (Hagel et al., 2004; Herve et al., 2012). In 1977, Sourander and Wålinder described a family with an autosomal dominant cerebrovascular disease manifesting with transient ischaemic attacks/strokes, neuropsychiatric symptoms and progressive cognitive decline. Thirty years later it...

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