Article
Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy.
PloS one - 1 Jan 2017
Capoor Manu N, Ruzicka Filip, Schmitz Jonathan E, James Garth A, Machackova Tana, Jancalek Radim, Smrcka Martin, Lipina Radim, Ahmed Fahad S, Alamin Todd F, Anand Neel, Baird John C, Bhatia Nitin, Demir-Deviren Sibel, Eastlack Robert K, Fisher Steve, Garfin Steven R, Gogia Jaspaul S, Gokaslan Ziya L, Kuo Calvin C, Lee Yu-Po, Mavrommatis Konstantinos, Michu Elleni, Noskova Hana, Raz Assaf, Sana Jiri, Shamie A Nick, Stewart Philip S, Stonemetz Jerry L, Wang Jeffrey C, Witham Timothy F, Coscia Michael F, Birkenmaier Christof, Fischetti Vincent A, Slaby Ondrej
Abstract excerpt
BACKGROUND: In previous studies, Propionibacterium acnes was cultured from intervertebral disc tissue of ~25% of patients undergoing microdiscectomy, suggesting a possible link between chronic bacterial infection and disc degeneration. However, given the prominence of P. acnes as a skin commensal, such analyses often struggled to exclude the alternate possibility that these organisms represent perioperative...
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