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Article

Effect of the interaction between MiR‐200b‐3p and DNMT 3A on cartilage cells of osteoarthritis patients

27 Mar 2017

Abstract excerpt

The aim of this research is to explore the effect of miR-200b-3p targeting DNMT3A on the proliferation and apoptosis of osteoarthritis (OA) cartilage cells. Quantitative RT-PCR was performed to analyse the expression of miR-200b-3p, DNMT3A, MMP1, MMP3, MMP9, MMP13 and COL II in normal and OA cartilage tissues. The dual-luciferase reporter assay and Western blot assay were conducted to confirm the targeting...

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PMID: 28345813
DOI: 10.1111/jcmm.13152

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