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Article

Prolactin regulation of the HPA axis is not mediated by a direct action upon CRH neurons: evidence from the rat and mouse.

Brain structure & function - 1 Sept 2017

Gustafson Papillon, Kokay Ilona, Sapsford Tony, Bunn Stephen, Grattan David

Abstract excerpt

Centrally acting prolactin has been shown to have anti-stress effects by modulating the activity of the hypothalamic-pituitary-adrenal axis. We tested the hypothesis that prolactin directly targets hypothalamic corticotropin-releasing hormone (CRH) neurons. In situ hybridisation confirmed expression of mRNA encoding the long, but not the short, isoform of the prolactin receptor (PRLR) within the paraventricular...

Topics

Action Potentials
Animals
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Corticotropin-Releasing Hormone
Female
Gene Expression Regulation
Green Fluorescent Proteins
Male
Mice
Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Transgenic

Mutation

Neurons

Paraventricular Hypothalamic Nucleus

Prolactin

RNA, Messenger

Rats

Rats, Sprague-Dawley

Source

Identifiers

PMID: 28337596
DOI: 10.1007/s00429-017-1395-1

Genes

CRH
PRLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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