Article
A functional variant in NEPH3 gene confers high risk of renal failure in primary hematuric glomerulopathies. Evidence for predisposition to microalbuminuria in the general population.
PloS one - 1 Jan 2017
Voskarides Konstantinos, Stefanou Charalambos, Pieri Myrtani, Demosthenous Panayiota, Felekkis Kyriakos, Arsali Maria, Athanasiou Yiannis, Xydakis Dimitris, Stylianou Kostas, Daphnis Eugenios, Goulielmos Giorgos, Loizou Petros, Savige Judith, Höhne Martin, Völker Linus A, Benzing Thomas, Maxwell Patrick H, Gale Daniel P, Gorski Mathias, Böger Carsten, Kollerits Barbara, Kronenberg Florian, Paulweber Bernhard, Zavros Michalis, Pierides Alkis, Deltas Constantinos
Abstract excerpt
BACKGROUND: Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a possible development for a subset of patients on long-term follow-up, through the onset of focal and segmental glomerulosclerosis (FSGS). We hypothesize that genetic modifiers may explain this...
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