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Comprehensive analysis to explain reduced or increased SOD1 enzymatic activity in ALS patients and their relatives

21 Mar 2017

Abstract excerpt

Objective: To characterise stabilities in erythrocytes of mutant SOD1 proteins, compare SOD1 enzymatic activities between patients with different genetic causes of ALS and search for underlying causes of deviant SOD1 activities in individuals lacking SOD1 mutations.Methods: Blood samples from 4072 individuals, ALS patients with or without a SOD1 mutation, family members and controls were studied. Erythrocyte SOD1...

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PMID: 28325066
DOI: 10.1080/21678421.2017.1301481

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