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Article

Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up.

Journal of cardiovascular translational research - 1 Apr 2017

Chimenti Isotta, Massai Diana, Morbiducci Umberto, Beltrami Antonio Paolo, Pesce Maurizio, Messina Elisa

Abstract excerpt

Improved protocols/devices for in vitro culture of 3D cell spheroids may provide essential cues for proper growth and differentiation of stem/progenitor cells (S/PCs) in their niche, allowing preservation of specific features, such as multi-lineage potential and paracrine activity. Several platforms have been employed to replicate these conditions and to generate S/PC spheroids for therapeutic applications....

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Identifiers

PMID: 28289983
DOI: 10.1007/s12265-017-9741-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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