Article
Mutations of CCNF gene is rare in patients with amyotrophic lateral sclerosis and frontotemporal dementia from Mainland China.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 May 2017
Pan Chuzheng, Jiao Bin, Xiao Tingting, Hou Lihua, Zhang Weiwei, Liu Xi, Xu Jun, Tang Beisha, Shen Lu
Abstract excerpt
OBJECTIVE: Mutations of the cyclin F (CCNF) gene were recently identified to be associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Western and Japanese populations. The rare protein-altering variants frequency is 0.6 to 3.3% in ALS and FTD from these diverse geographic populations while no systematic analysis of CCNF variants were conducted in the Chinese population. METHODS:...
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