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Article

Defective DNA repair mechanisms in prostate cancer: impact of olaparib

1 Mar 2017

Abstract excerpt

The field of prostate oncology has continued to change dramatically. It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition and aggressiveness. Poly adenosine diphosphate ribose polymerase (PARP)...

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PMID: 28280302
DOI: 10.2147/dddt.s110264

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