Article
Study on the glutathione metabolism of the filamentous fungus Aspergillus nidulans.
Acta microbiologica et immunologica Hungarica - 1 Sept 2017
Bakti Fruzsina, Király Anita, Orosz Erzsébet, Miskei Márton, Emri Tamás, Leiter Éva, Pócsi István
Abstract excerpt
Yeast protein sequence-based homology search for glutathione (GSH) metabolic enzymes and GSH transporters demonstrated that Aspergillus nidulans has a robust GSH uptake and metabolic system with several paralogous genes. In wet laboratory experiments, two key genes of GSH metabolism, gcsA, and glrA, encoding γ-l-glutamyl-l-cysteine synthetase and glutathione reductase, respectively, were deleted. The gene gcsA...
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