Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.

doi:10.1016/j.stemcr.2017.01.027

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Article

Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells.

Stem cell reports - 14 Mar 2017

Yang Jiayin, Wang Yu, Zhou Ting, Wong Lai-Yung, Tian Xiao-Yu, Hong Xueyu, Lai Wing-Hon, Au Ka-Wing, Wei Rui, Liu Yuqing, Cheng Lai-Hung, Liang Guichan, Huang Zhijian, Fan Wenxia, Zhao Ping, Wang Xiwei, Ibañez David P, Luo Zhiwei, Li Yingying, Zhong Xiaofen, Chen Shuhan, Wang Dongye, Li Li, Lai Liangxue, Qin Baoming, Bao Xichen, Hutchins Andrew P, Siu Chung-Wah, Huang Yu, Esteban Miguel A, Tse Hung-Fat

Abstract excerpt

Familial hypercholesterolemia (FH) causes elevation of low-density lipoprotein cholesterol (LDL-C) in blood and carries an increased risk of early-onset cardiovascular disease. A caveat for exploration of new therapies for FH is the lack of adequate experimental models. We have created a comprehensive FH stem cell model with differentiated hepatocytes (iHeps) from human induced pluripotent stem cells (iPSCs),...

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Identifiers

PMID: 28262545
DOI: 10.1016/j.stemcr.2017.01.027
PMCID: PMC5355732

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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