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Article

Gene Therapy Restores Balance and Auditory Functions in a Mouse Model of Usher Syndrome.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2017

Isgrig Kevin, Shteamer Jack W, Belyantseva Inna A, Drummond Meghan C, Fitzgerald Tracy S, Vijayakumar Sarath, Jones Sherri M, Griffith Andrew J, Friedman Thomas B, Cunningham Lisa L, Chien Wade W

Abstract excerpt

Dizziness and hearing loss are among the most common disabilities. Many forms of hereditary balance and hearing disorders are caused by abnormal development of stereocilia, mechanosensory organelles on the apical surface of hair cells in the inner ear. The deaf whirler mouse, a model of human Usher syndrome (manifested by hearing loss, dizziness, and blindness), has a recessive mutation in the whirlin gene, which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28254438
DOI: 10.1016/j.ymthe.2017.01.007
PMCID: PMC5363211

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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