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Article

3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2017

Nagae Masamichi, Mishra Sushil K, Neyazaki Makiko, Oi Rika, Ikeda Akemi, Matsugaki Naohiro, Akashi Satoko, Manya Hiroshi, Mizuno Mamoru, Yagi Hirokazu, Kato Koichi, Senda Toshiya, Endo Tamao, Nogi Terukazu, Yamaguchi Yoshiki

Abstract excerpt

Orchestration of the multiple enzymes engaged in O-mannose glycan synthesis provides a matriglycan on α-dystroglycan (α-DG) which attracts extracellular matrix (ECM) proteins such as laminin. Aberrant O-mannosylation of α-DG leads to severe congenital muscular dystrophies due to detachment of ECM proteins from the basal membrane. Phosphorylation at C6-position of O-mannose catalyzed by protein O-mannosyl kinase...

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Source

Identifiers

PMID: 28251761
DOI: 10.1111/gtc.12480

Genes

POMK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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