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Mutations inblaKPC-3That Confer Ceftazidime-Avibactam Resistance Encode Novel KPC-3 Variants That Function as Extended-Spectrum β-Lactamases

22 Feb 2017

Abstract excerpt

ABSTRACT We identified fourblaKPC-3mutations in ceftazidime-avibactam-resistant clinical Klebsiella pneumoniae isolates, corresponding to D179Y, T243M, D179Y/T243M, and EL165-166 KPC-3 variants. Using site-directed mutagenesis and transforming vectors into Escherichia coli , we conclusively demonstrated that mutantblaKPC-3encoded enzymes that functioned as extended-spectrum β-lactamases; mutations directly...

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PMID: 28223379
DOI: 10.1128/aac.02534-16

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