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Treating Cancer by Targeting Telomeres and Telomerase

19 Feb 2017

Abstract excerpt

Telomerase is expressed in more than 85% of cancer cells. Tumor cells with metastatic potential may have a high telomerase activity, allowing cells to escape from the inhibition of cell proliferation due to shortened telomeres. Human telomerase primarily consists of two main components: hTERT, a catalytic subunit, and hTR, an RNA template whose sequence is complimentary to the telomeric 5'-dTTAGGG-3' repeat. In...

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PMID: 28218725
DOI: 10.3390/antiox6010015

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