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Matrix attachment region combinations increase transgene expression in transfected Chinese hamster ovary cells

20 Feb 2017

Abstract excerpt

Matrix attachment regions (MARs) are cis-acting DNA elements that can increase transgene expression levels in a CHO cell expression system. To investigate the effects of MAR combinations on transgene expression and the underlying regulatory mechanisms, we generated constructs in which the enhanced green fluorescent protein (eGFP) gene flanked by different combinations of human β-interferon and β-globin MAR (iMAR...

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PMID: 28216629
DOI: 10.1038/srep42805

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