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Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis

30 Jan 2017

Abstract excerpt

Overexpression of IL-6 has been proposed to contribute to pulmonary fibrosis and other fibrotic diseases. However, the regulatory mechanisms as well as the role of IL-6 in fibrosis remain poorly understood. Epigenetics refers to alterations of gene expression without changes in the DNA sequence. Alternation of chromatin accessibility by histone acetylation acts as a critical epigenetic mechanism to regulate a...

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PMID: 28194150
DOI: 10.3389/fimmu.2016.00696

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