Article
Genomic Variant in IL-37 Confers A Significant Risk of Coronary Artery Disease.
Scientific reports - 9 Feb 2017
Yin Dan, Naji Duraid Hamied, Xia Yunlong, Li Sisi, Bai Ying, Jiang Guiqing, Zhao Yuanyuan, Wang Xiaojing, Huang Yufeng, Chen Shanshan, Fa Jingjing, Tan Chengcheng, Zhou Mengchen, Zhou Yingchao, Wang Longfei, Liu Ying, Chen Feifei, Liu Jingqiu, Chen Qiuyun, Tu Xin, Xu Chengqi, Wang Qing K
Abstract excerpt
The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic inflammatory disease. However, the genetic association between IL-37, the seventh member of the IL-1 family, and CAD is unknown. Here we show that a single nucleotide polymorphism in the IL-37 gene (rs3811047) confers a significant risk of CAD. We have performed an association...
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