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Article

IMHOTEP-a composite score integrating popular tools for predicting the functional consequences of non-synonymous sequence variants.

Nucleic acids research - 17 Feb 2017

Knecht Carolin, Mort Matthew, Junge Olaf, Cooper David N, Krawczak Michael, Caliebe Amke

Abstract excerpt

The in silico prediction of the functional consequences of mutations is an important goal of human pathogenetics. However, bioinformatic tools that classify mutations according to their functionality employ different algorithms so that predictions may vary markedly between tools. We therefore integrated nine popular prediction tools (PolyPhen-2, SNPs&GO, MutPred, SIFT, MutationTaster2, Mutation Assessor and...

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Identifiers

PMID: 28180317
DOI: 10.1093/nar/gkw886
PMCID: PMC5388428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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