Kaposi's sarcoma‐associated herpesvirus (KSHV)‐encoded microRNAs promote matrix metalloproteinases (MMPs) expression and pro‐angiogenic cytokine secretion in endothelial cells

Abstract excerpt

The human oncogenic virus Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to Kaposi's sarcoma (KS), a tumor of endothelial cells characterized by angiogenesis and invasiveness. KSHV genome encodes 25 mature microRNAs (miRNAs), but their roles in KSHV-induced tumor dissemination and angiogenesis are not fully understood. In this study, we constructed the sensor reporters of KSHV miRNAs and used a...

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