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Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

1 Feb 2017

Abstract excerpt

BACKGROUND: The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In order to be able to eradicate these CSCs with novel classes of anti-cancer therapeutics, a better understanding of their biology and clinically-relevant traits is mandatory. MAIN BODY: Several...

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PMID: 28148265
DOI: 10.1186/s12943-017-0595-x

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