Article
[Clinical course and phenotypic instability in 4 cases of multiple myeloma: a biological model of tumors].
Medicina (Florence, Italy) - 1 Jan 2000
Seminara P, Franchi F, Pisanelli G C, Abdolrahimzadeh S, Aronne T, Afeltra A, Bonomo L
Abstract excerpt
Four cases of multiple myeloma (MM) are reported in which the coexistence and/or the alternance of different plasma cell clones were observed. Genetic instability is typical of all tumors but in MM it is particularly striking due to the M component marker. In this respect, malignancies reveal the presence of an unremitting competition of different cell populations for the phenotype prevalence. When this...
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