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Article

Mechanism of type-III protein secretion: Regulation of FlhA conformation by a functionally critical charged-residue cluster.

Molecular microbiology - 1 Apr 2017

Erhardt Marc, Wheatley Paige, Kim Eun A, Hirano Takanori, Zhang Yang, Sarkar Mayukh K, Hughes Kelly T, Blair David F

Abstract excerpt

The bacterial flagellum contains a specialized secretion apparatus in its base that pumps certain protein subunits through the growing structure to their sites of installation beyond the membrane. A related apparatus functions in the injectisomes of gram-negative pathogens to export virulence factors into host cells. This mode of protein export is termed type-III secretion (T3S). Details of the T3S mechanism are...

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Identifiers

PMID: 28106310
DOI: 10.1111/mmi.13623
PMCID: PMC5380474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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