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Article

A taxonomy of medical uncertainties in clinical genome sequencing.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2017

Han Paul K J, Umstead Kendall L, Bernhardt Barbara A, Green Robert C, Joffe Steven, Koenig Barbara, Krantz Ian, Waterston Leo B, Biesecker Leslie G, Biesecker Barbara B

Abstract excerpt

PURPOSE: Clinical next-generation sequencing (CNGS) is introducing new opportunities and challenges into the practice of medicine. Simultaneously, these technologies are generating uncertainties of an unprecedented scale that laboratories, clinicians, and patients are required to address and manage. We describe in this report the conceptual design of a new taxonomy of uncertainties around the use of CNGS in...

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Identifiers

PMID: 28102863
DOI: 10.1038/gim.2016.212
PMCID: PMC5517355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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