Article
Mechanistic insights into type I toxin antitoxin systems in <i>Helicobacter pylori:</i> the importance of mRNA folding in controlling toxin expression
22 Dec 2016
Abstract excerpt
Type I toxin-antitoxin (TA) systems have been identified in a wide range of bacterial genomes. Here, we report the characterization of a new type I TA system present on the chromosome of the major human gastric pathogen, Helicobacter pylori. We show that the aapA1 gene encodes a 30 amino acid peptide whose artificial expression in H. pylori induces cell death. The synthesis of this toxin is prevented by the...
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