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Article

Reverse Pathway Genetic Approach Identifies Epistasis in Autism Spectrum Disorders.

PLoS genetics - 1 Jan 2017

Mitra Ileena, Lavillaureix Alinoë, Yeh Erika, Traglia Michela, Tsang Kathryn, Bearden Carrie E, Rauen Katherine A, Weiss Lauren A

Abstract excerpt

Although gene-gene interaction, or epistasis, plays a large role in complex traits in model organisms, genome-wide by genome-wide searches for two-way interaction have limited power in human studies. We thus used knowledge of a biological pathway in order to identify a contribution of epistasis to autism spectrum disorders (ASDs) in humans, a reverse-pathway genetic approach. Based on previous observation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28076348
DOI: 10.1371/journal.pgen.1006516
PMCID: PMC5226683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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