Previous miscarriages and GLI2 are associated with anorectal malformations in offspring.

doi:10.1093/humrep/dew327

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Previous miscarriages and GLI2 are associated with anorectal malformations in offspring.

Human reproduction (Oxford, England) - 1 Feb 2017

van de Putte Romy, Wijers Charlotte H W, de Blaauw Ivo, Marcelis Carlo L M, Sloots Cornelius E J, Brooks Alice S, Broens Paul M A, Roeleveld Nel, van der Zanden Loes F M, van Rooij Iris A L M

Abstract excerpt

STUDY QUESTION: Are anorectal malformations (ARMs) associated with previous miscarriages or single nucleotide polymorphisms (SNPs) in the Bone Morphogenetic Protein 4 (BMP4) and GLI family zinc finger 2 (GLI2) genes? SUMMARY ANSWER: The SNP rs3738880 in GLI2 and miscarriages were associated with ARM, especially in patients with multiple congenital anomalies (MCA). WHAT IS KNOWN ALREADY: ARM are one of the most...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abortion, Habitual

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Protein 4

Share to Case-Control Studies

Share to Infant, Newborn

Share to Nuclear Proteins

Share to Pregnancy

Share to Surveys and Questionnaires

Share to Zinc Finger Protein Gli2

Source

Open in PubMed

Identifiers

PMID: 28057877
DOI: 10.1093/humrep/dew327

Genes

GLI2
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Previous miscarriages and GLI2 are associated with anorectal malformations in offspring.PMID 28057877Read ↗

Genetics of Recurrent Miscarriage and Pregnancy Loss in Women’s Reproductive HealthSemantic proximity Read ↗

The genetic architecture of sporadic and multiple consecutive miscarriage.Semantic proximity Read ↗

The Role of De Novo Variants in Formation of Human Anorectal Malformations.Semantic proximity Read ↗

The genetic architecture of sporadic and recurrent miscarriageSemantic proximity Read ↗

Research perspectives in the etiology of congenital anorectal malformations using data of the International Consortium on Anorectal Malformations: evidence for risk factors across different populationsSemantic proximity Read ↗

Relationship between HLA-G polymorphism and susceptibility to recurrent miscarriage: a meta-analysis of non-family-based studies.Semantic proximity Read ↗

Epidemiologic analysis of families with isolated anorectal malformations suggests high prevalence of autosomal dominant inheritanceSemantic proximity Read ↗

Anorectal malformation: the etiological factors.Semantic proximity Read ↗

Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy.Semantic proximity Read ↗

Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas.Semantic proximity Read ↗

Miscarriage and Its AssociationsSemantic proximity Read ↗

Anorectal atresia and variants at predicted regulatory sites in candidate genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.