Clinical settings in knee osteoarthritis: Pathophysiology guides treatment.

Abstract excerpt

Osteoarthritis (OA) is the most common chronic joint disorder and its prevalence increases rapidly during midlife. Complex interactions of genetic alterations, sex hormone deficit, and aging with mechanical factors and systemic inflammation-associated metabolic syndrome lead to joint damage. Thus, the expression of a clinical phenotype in the early stages of OA relies on the main underlying pathway and...

Topics

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• Biomechanical Phenomena
• Inflammation
• Metabolic Diseases
• Osteoarthritis, Knee
• Osteoporosis