Article
Gene expression profiling of tumor-initiating stem cells from mouse Krebs-2 carcinoma using a novel marker of poorly differentiated cells.
Oncotarget - 7 Feb 2017
Potter Ekaterina A, Dolgova Evgenia V, Proskurina Anastasia S, Efremov Yaroslav R, Minkevich Alexandra M, Rozanov Aleksey S, Peltek Sergey E, Nikolin Valeriy P, Popova Nelly A, Seledtsov Igor A, Molodtsov Vladimir V, Zavyalov Evgeniy L, Taranov Oleg S, Baiborodin Sergey I, Ostanin Alexander A, Chernykh Elena R, Kolchanov Nikolay A, Bogachev Sergey S
Abstract excerpt
Using the ability of poorly differentiated cells to natively internalize fragments of extracellular double-stranded DNA as a marker, we isolated a tumorigenic subpopulation present in Krebs-2 ascites that demonstrated the features of tumor-inducing cancer stem cells. Having combined TAMRA-labeled DNA probe and the power of RNA-seq technology, we identified a set of 168 genes specifically expressed in...
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