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Article

Transgenic TBK1 mice have features of normal tension glaucoma.

Human molecular genetics - 1 Jan 2017

Fingert John H, Miller Kathy, Hedberg-Buenz Adam, Roos Ben R, Lewis Carly J, Mullins Robert F, Anderson Michael G

Abstract excerpt

Duplication of the TBK1 gene is associated with 1-2% of normal tension glaucoma, a common cause of vision loss and blindness that occurs without grossly abnormal intraocular pressure. We generated a transgenic mouse that has one copy of the human TBK1 gene (native promoter and gene structure) incorporated into the mouse genome (Tg-TBK1). Expression of the TBK1 transgene in the retinae of these mice was...

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Share to Disease Models, Animal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

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Share to Protein Serine-Threonine Kinases

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Source

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Identifiers

PMID: 28025332
DOI: 10.1093/hmg/ddw372
PMCID: PMC6075615

Genes

TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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