Article
TBK1 gene duplication and normal-tension glaucoma.
JAMA ophthalmology - 1 May 2014
Ritch Robert, Darbro Ben, Menon Geeta, Khanna Cheryl L, Solivan-Timpe Frances, Roos Ben R, Sarfarzi Mansoor, Kawase Kazuhide, Yamamoto Tetsuya, Robin Alan L, Lotery Andrew J, Fingert John H
Abstract excerpt
IMPORTANCE: Normal-tension glaucoma (NTG) is a common cause of vision loss. OBJECTIVE: To investigate the role of TANK binding kinase 1 (TBK1) gene duplications in NTG to gain insights into the causes of glaucoma that occurs at low intraocular pressure (IOP). DESIGN, SETTING, AND PARTICIPANTS: In this multicenter case-control study, we investigated patients who met the criteria for NTG, including glaucomatous...
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