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Deficiency of succinyl-CoA synthetase α subunit delays development, impairs locomotor activity and reduces survival under starvation in Drosophila.

Biochemical and biophysical research communications - 29 Jan 2017

Quan Xiuming, Sato-Miyata Yukiko, Tsuda Manabu, Muramatsu Keigo, Asano Tsunaki, Takeo Satomi, Aigaki Toshiro

Abstract excerpt

Succinyl-CoA synthetase/ligase (SCS) is a mitochondrial enzyme that catalyzes the reversible process from succinyl-CoA to succinate and free coenzyme A in TCA cycle. SCS deficiencies are implicated in mitochondrial hepatoencephalomyopathy in humans. To investigate the impact of SCS deficiencies in Drosophila, we generated a null mutation in Scs alpha subunit (Scsα) using the CRISPR/Cas9 system, and characterized...

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Acyl Coenzyme A
Citric Acid Cycle
Energy Metabolism
Food Deprivation
Glycogen

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PMID: 28017724
DOI: 10.1016/j.bbrc.2016.12.105

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