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Therapeutic efficacy of peramivir against H5N1 highly pathogenic avian influenza viruses harboring the neuraminidase H275Y mutation.

Antiviral research - 1 Mar 2017

Kobayashi Masanori, Kodama Makoto, Noshi Takeshi, Yoshida Ryu, Kanazu Takushi, Nomura Naoki, Soda Kosuke, Isoda Norikazu, Okamatsu Masatoshi, Sakoda Yoshihiro, Yamano Yoshinori, Sato Akihiko, Kida Hiroshi

Abstract excerpt

High morbidity and mortality associated with human cases of highly pathogenic avian influenza (HPAI) viruses, including H5N1 influenza virus, have been reported. The purpose of the present study was to evaluate the antiviral effects of peramivir against HPAI viruses. In neuraminidase (NA) inhibition and virus replication inhibition assays, peramivir showed strong inhibitory activity against H5N1, H7N1 and H7N7...

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Identifiers

PMID: 28012921
DOI: 10.1016/j.antiviral.2016.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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