Article
The effects of a skeletal muscle titin mutation on walking in mice.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology - 1 Jan 2017
Pace Cinnamon M, Mortimer Sarah, Monroy Jenna A, Nishikawa Kiisa C
Abstract excerpt
Titin contributes to sarcomere assembly, muscle signaling, and mechanical properties of muscle. The mdm mouse exhibits a small deletion in the titin gene resulting in dystrophic mutants and phenotypically normal heterozygotes. We examined the effects of this mutation on locomotion to assess how, and if, changes to muscle phenotype explain observed locomotor differences. Mutant mice are much smaller in size than...
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