Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

doi:10.1016/j.ccell.2016.11.004

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Molecular Liver Cancer Prevention in Cirrhosis by Organ Transcriptome Analysis and Lysophosphatidic Acid Pathway Inhibition.

Cancer cell - 12 Dec 2016

Nakagawa Shigeki, Wei Lan, Song Won Min, Higashi Takaaki, Ghoshal Sarani, Kim Rosa S, Bian C Billie, Yamada Suguru, Sun Xiaochen, Venkatesh Anu, Goossens Nicolas, Bain Gretchen, Lauwers Gregory Y, Koh Anna P, El-Abtah Mohamed, Ahmad Noor B, Hoshida Hiroki, Erstad Derek J, Gunasekaran Ganesh, Lee Youngmin, Yu Ming-Lung, Chuang Wan-Long, Dai Chia-Yen, Kobayashi Masahiro, Kumada Hiromitsu, Beppu Toru, Baba Hideo, Mahajan Milind, Nair Venugopalan D, Lanuti Michael, Villanueva Augusto, Sangiovanni Angelo, Iavarone Massimo, Colombo Massimo, Llovet Josep M, Subramanian Aravind, Tager Andrew M, Friedman Scott L, Baumert Thomas F, Schwarz Myron E, Chung Raymond T, Tanabe Kenneth K, Zhang Bin, Fuchs Bryan C, Hoshida Yujin

Abstract excerpt

Cirrhosis is a milieu that develops hepatocellular carcinoma (HCC), the second most lethal cancer worldwide. HCC prediction and prevention in cirrhosis are key unmet medical needs. Here we have established an HCC risk gene signature applicable to all major HCC etiologies: hepatitis B/C, alcohol, and non-alcoholic steatohepatitis. A transcriptome meta-analysis of >500 human cirrhotics revealed global regulatory...

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Identifiers

PMID: 27960085
DOI: 10.1016/j.ccell.2016.11.004
PMCID: PMC5161110

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