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In Silico Knockout Studies of Xenophagic Capturing of Salmonella

1 Dec 2016

Abstract excerpt

The degradation of cytosol-invading pathogens by autophagy, a process known as xenophagy, is an important mechanism of the innate immune system. Inside the host, Salmonella Typhimurium invades epithelial cells and resides within a specialized intracellular compartment, the Salmonella-containing vacuole. A fraction of these bacteria does not persist inside the vacuole and enters the host cytosol. Salmonella...

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PMID: 27906974
DOI: 10.1371/journal.pcbi.1005200

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