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Article

DISCOVERY OF FUNCTIONAL AND DISEASE PATHWAYS BY COMMUNITY DETECTION IN PROTEIN-PROTEIN INTERACTION NETWORKS.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2017

Wilson Stephen J, Wilkins Angela D, Lin Chih-Hsu, Lua Rhonald C, Lichtarge Olivier

Abstract excerpt

Advances in cellular, molecular, and disease biology depend on the comprehensive characterization of gene interactions and pathways. Traditionally, these pathways are curated manually, limiting their efficient annotation and, potentially, reinforcing field-specific bias. Here, in order to test objective and automated identification of functionally cooperative genes, we compared a novel algorithm with three...

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PMID: 27896987
DOI: 10.1142/9789813207813_0032
PMCID: PMC5140035

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