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Article

World’s First Clinical Case of Gene-Activated Bone Substitute Application

1 Jan 2016

Abstract excerpt

Treatment of patients with large bone defects is a complex clinical problem. We have initiated the first clinical study of a gene-activated bone substitute composed of the collagen-hydroxyapatite scaffold and plasmid DNA encoding vascular endothelial growth factor. The first patient with two nonunions of previously reconstructed mandible was enrolled into the study. Scar tissues were excised; bone defects (5-14...

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PMID: 27891264
DOI: 10.1155/2016/8648949

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