Article
Root cause analysis of limitations of virtual crossmatch for kidney allocation to highly-sensitized patients.
Human immunology - 1 Feb 2017
Jani Vivek, Ingulli Elizabeth, Mekeel Kristen, Morris Gerald P
Abstract excerpt
Efficient allocation of deceased donor organs depends upon effective prediction of immunologic compatibility based on donor HLA genotype and recipient alloantibody profile, referred to as virtual crossmatching (VCXM). VCXM has demonstrated utility in predicting compatibility, though there is reduced efficacy for patients highly sensitized against allogeneic HLA antigens. The recently revised deceased donor kidney...
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