Article
A review of maturity onset diabetes of the young (MODY) and challenges in the management of glucokinase-MODY.
The Medical journal of Australia - 21 Nov 2016
Bishay Ramy H, Greenfield Jerry R
Abstract excerpt
Maturity onset diabetes of the young (MODY), the most common monogenic form of diabetes, accounts for 1-2% of all diabetes diagnoses. Glucokinase (GCK)-MODY (also referred to as MODY2) constitutes 10-60% of all MODY cases and is inherited as an autosomal dominant heterozygous mutation, resulting in loss of function of the GCK gene. Patients with GCK-MODY generally have mild, fasting hyperglycaemia that is present...
Topics
- Blood Glucose
- Diabetes Mellitus, Type 2
- Female
- Genetic Testing
- Humans
- Hyperglycemia
- Hypoglycemic Agents
- Insulin
- Insulin Resistance
- Metformin
- Middle Aged
- Mutation