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Article

Clinical and imaging characteristics of late onset mitochondrial membrane protein-associated neurodegeneration (MPAN).

Neurocase - 1 Oct 2016

Gore Ethan, Appleby Brian S, Cohen Mark L, DeBrosse Suzanne D, Leverenz James B, Miller Bruce L, Siedlak Sandra L, Zhu Xiongwei, Lerner Alan J

Abstract excerpt

Young onset dementias present significant diagnostic challenges. We present the case of a 35-year-old Kuwaiti man with social withdrawal, drowsiness, irritability, anxiety, aphasia, memory loss, hypereflexia, and Parkinsonism. Brain MRI showed bilateral symmetric gradient echo hypointensities in the globi pallidi and substantiae nigrae. Left cortical hypometabolism was seen on brain fluorodeoxyglucose positron...

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Identifiers

PMID: 27801611
DOI: 10.1080/13554794.2016.1247458
PMCID: PMC5568540

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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