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Article

A Pyrosequencing-Based Approach to High-Throughput Identification of Influenza A(H3N2) Virus Clades Harboring Antigenic Drift Variants.

Journal of clinical microbiology - 1 Jan 2017

Mishin Vasiliy P, Baranovich Tatiana, Garten Rebecca, Chesnokov Anton, Abd Elal Anwar I, Adamczyk Michelle, LaPlante Jennifer, St George Kirsten, Fry Alicia M, Barnes John, Chester Stephanie C, Xu Xiyan, Katz Jacqueline M, Wentworth David E, Gubareva Larisa V

Abstract excerpt

The rapid evolution of influenza A(H3N2) viruses necessitates close monitoring of their antigenic properties so the emergence and spread of antigenic drift variants can be rapidly identified. Changes in hemagglutinin (HA) acquired by contemporary A(H3N2) viruses hinder antigenic characterization by traditional methods, thus complicating vaccine strain selection. Sequence-based approaches have been used to infer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to High-Throughput Nucleotide Sequencing

Share to Influenza A Virus, H3N2 Subtype

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 27795346
DOI: 10.1128/JCM.01840-16
PMCID: PMC5228225

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