Article
Peripheral T cell responses to tumour antigens are associated with molecular, immunogenetic and cellular features of breast cancer patients.
Breast cancer research and treatment - 1 Jan 2017
Janssen Nicole, Fortis Sotirios P, Speigl Lisa, Haritos Christoforos, Sotiriadou Nectaria N, Sofopoulos Michael, Arnogiannaki Niki, Stavropoulos-Giokas Catherine, Dinou Amalia, Perez Sonia, Pawelec Graham, Baxevanis Constantin N, Shipp Christopher
Abstract excerpt
PURPOSE: Breast cancer is a leading cause of cancer deaths in women, but despite steady improvements in therapies, treatment is still suboptimal. Immunotherapy holds promise as a more effective therapy for breast cancer; supporting this, our prior study showed that patients possessing HER2-reactive CD8+ T cells in blood experience survival superior to patients without these cells. Here, we define a composite set...
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